Synthesis of N-substituted aminoalkyl derivatives of some epoxyisoindoles as potential pharmacological agents.

Grogan and Rice reported a number of imides of epoxyisoindole sort. Some pharmacological testing was performed which revealed their bioactivity. Except of their work, only scattered examples of derivatives with oxygen-bridged ring have appeared in the literature; this approach has also been used by us in the synthesis of some new potential drugs. This paper reports the synthesis of a number of epoxyisoindole derivatives, as well as in vitro tests of some selected representants.